β-blocking wounds

The protective effect of propofol on hydrogen peroxide-induced human esophageal carcinoma via blocking the Wnt/β-catenin signaling pathway

Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin signaling pathway.Materials and Methods: Eca109 cells were classified into 5 groups: Control group, H2O2 group, Propofol + H2O2 group, Dkk1 (Dickkopf-1, Wnt/β-catenin pathway antagonist) + H2O2 group...

Directed Blocking of TGF-β Receptor I Binding Site Using Tailored Peptide Segments to Inhibit its Signaling Pathway

Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind and bring the receptors (TβRII and TβRI) together to form a signaling complex in an ordered manner. Objectives: Herein, an antagonistic variant of TGF-β (AnTβ)...

Wounds.

A 23-year-old man living in Orange County, California who was involved in a motor vehicle accident suffered a closed both-bone forearm fracture that was treated with open reduction and internal fixation. The patient then developed wound necrosis and abscesses that revealed a pure culture of non-toxigenic Vibrio cholerae. The wound required debridement and excision, which was followed by split-t...

Acute WOUNDS

Of those affected, 90% are women. This is because most of these injuries occur in the home when older women are carrying out domestic chores. Another risk factor is the wearing of skirts, which do not provide protection from injuries that trousers maybe would. Women are also at risk due to skin changes that occur as a result of decreasing hormone levels (Laing et al, 2002; Sussman and Golding, ...

Gunshot Wounds